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Once a patient is on a maintenance dose, their B12 levels are generally stable, and a single days difference is unlikely to have a clinical impact

For people with absorption issues (and most adults over 50 have at least some), oral B12 simply doesnt deliver enough cobalamin to make a felt difference

Pernicious anemia is a very rare autoimmune disorder that does not allow for proper vitamin B12 absorption which ultimately leads individuals to have an irreversible deficiency in this vitamin

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