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Further research is needed to elucidate the basic mechanism underpinning T and B-cell recruitment into an immune response, to examine antibody affinity maturation and to identify the determinants of the immunodominance hierarchy for T and B-cell epitopes, which ultimately may enable vaccine antigens to be rationally designed to induce broadly targeted immunity

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These patients rely solely on their innate antiviral immune responses in the first stages of infection, which increases the risk of cytokine storms, severe disease onset, and mortality (Wang et al., 2020a)