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Open-source packages and libraries and corresponding versions used during the computational analysis are described in the Methods and Reporting Summary

Excess body fat has been demonstrated to exert a substantial influence on the reproductive health of males, through its capacity to disrupt hormonal regulation, to engender increased oxidative stress, and to impair testicular function

Future clinical research endeavors should consider the various features that modulate NIMETOX pathways, specifically the ROI and MetS, as well as the various phenotypes of MDD and the phase of the index episode, when this disorder is investigated through the application of advanced machine learning-based composite scores to assess NIMETOX functions