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Mol Genet Genomic Med 2(1):7380 Lim SC, Friemel M, Marum JE, Tucker EJ, Bruno DL, Riley LG, Christodoulou J, Kirk EP, Boneh A, DeGennaro CM, Springer M, Mootha VK, Rouault TA, Leimkhler S, Thorburn DR, Compton AG (2013) Mutations in LYRM4, encoding iron-sulfur cluster biogenesis factor ISD11, cause deficiency of multiple respiratory chain complexes

However, ASS1 is frequently downregulated in fibrotic lung tissues, which promotes fibroblast activation through STAT3 signaling and drives an aggressive, apoptosis-resistant phenotype [87, 88]

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These findings also strongly suggest that L-serine in the CNS is exclusively synthesized by astrocytes

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