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Oxidative stress also activates the Kelch-like ECH-associated protein 1 (Keap1)-Nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response element (ARE) redox regulator pathway, releasing Nrf2 to regulate the expression of genes that control antioxidant, inflammatory and immune system responses, facilitating GSH activity

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Yet, under normal circumstances, uptake of supplemental coenzyme Q 10 from peripheral tissues/organs is likely limited because coenzyme Q 10 is ubiquitously synthesized (105)

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