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Metabolomic profiling supported these transcriptomic and epigenomic changes, revealing altered levels of several metabolites associated with AKT1-driven pathways, including arginine, NADP, glycerol, guanosine, and glutamate

GPX4 localizes not only in the cytosol but also within the mitochondria, where it detoxifies the phospholipid hydroperoxides generated by MitoROS (90,91)

J.MacKayG.NixonC.et al (2017)

Antitumour activity of S-p-bromobenzylgluta thione cyclopentyl diester in vitro and in vivo

The non-staining cells were also analyzed as the auto-fluorescence reference

After 1 day of transfection, cells in the six-well plate were digested and resuspended in complete medium DMEM (5% FBS, 1% antibiotic) and plated in a 96-well flat-bottomed white microplate