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MOTS-c was found to upregulate key genes in the TGF-/Smad pathway (such as TGF-1, TGF-2, and Smad7) and increase the expression of bone formation markers like alkaline phosphatase (ALP), osteocalcin, and Runx2 in bone cells

Reduced mitochondrial DNA copy number in Chinese patients with osteosarcoma

This pathogen utilizes vomocytosis (non-lytic expulsion) to escape from the phagolysosome in 10-27% of cases and within the initial 10 hours of infection (time varies between host types) (264)

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Funding This research received support from the 2023 Project Foundation of Tianjin Baodi Hospital (Grant No

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