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In summary, significant biological differences were identified between participants with LC and demographically and medically matched CC and HC participants, validating extensive reports of persistent symptoms by various individuals with LC and patient advocacy groups

Statistical analysis Functional enrichment analysis of differential metabolites in rumen fluid and longissimus dorsi muscle Metabolites with significant differences between the two groups were selected based on t -test p -values and fold change (FC, H-IMF/L-IMF)

This reduction is likely an adaptive response to the high metabolic and mechanical stress associated with these sports, rather than an indication of underlying pathology