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Under hypoxic conditions, L-2-hydroxyglutarate (L-2-HG) was proven to be generated by lactate dehydrogenase A (LDHA) and malate dehydrogenase (MDH) 88,89

Overexpression of the C-terminus of GSTM2 decreased the p-ASK1 level, whereas N-terminal overexpression did not (Fig

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Pretreatment with GHK-Cu strongly promoted Nrf2 expression while significantly reducing the level of Keap1 in the cytoplasm compared to the CS group (Figures 4A,C,D)

(2019) investigated the effect of a novel penetrating peptide-guided nanoparticles that targets cell surface LinTT1, p32 for glioblastoma targeting

The lungs rely heavily on glycolysis, fatty acid oxidation, and other metabolic pathways to meet these diverse energy requirements (Figure 2)