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Hypoxic mice were administered hypoxic treatment in a closed hypoxic chamber (China Innovation Instrument Co., Ltd, Ningbo, Zhejiang, China), which accurately set the desired hypoxic concentration and pattern

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Daily injections of mitragynine (1, 30 mg/kg) and morphine (10 mg/kg) were given for 1 and 4 days in separate groups of rats

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(2) BPC 157 promotes the vessel relaxation mainly acting on vascular endothelial cells but much less on vascular smooth muscle cells

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