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NNMT was confirmed to be upregulated in aged versus young mouse skeletal muscle

That distinction matters in a category where "copper peptide" is increasingly used as a marketing term rather than as proof of potency.

Retrieved February 19, 2022

Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome

It means that a significant portion of the orally administered 5-Amino-1MQ might not actually reach systemic circulation in its active form, or at least not at the desired concentration