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Absorbance measurements were performed using a microplate reader, model MR9600 (Accuris Instruments, New Jersey, United States)

Moreover, the HIV infection also causes mild neurocognitive disorder and demyelinating neuropathy with motor and sensory impairments

This finding supports the notion that nanoparticles can alter the physicochemical properties of hydrophobic compounds (FIN and CUR), thereby expanding their therapeutic potential

10.1038/ni972 [DOI] [PubMed] [Google Scholar] 97

Once it enters the cytoplasm, a part of Cu + binds to glutathione (GSH) and is delivered to metallothionein 1/2 (MT1/2) to be restored, and other parts of Cu + are either transferred to the nucleus or ATP7A/7B located in the trans-Golgi network (TGN) by the chaperone antioxidant-1(ATOX1) to facilitate the synthesis of cuproenzymes (Lutsenko et al., 2007) or delivered to superoxide dismutase 1 (SOD1) in the cytoplasm and mitochondrial intermembrane space by a copper chaperone for superoxide dismutase (CCS) to detoxify reactive oxygen species (ROS)