Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-Exatecan deuterium-labeled-ether CA-amide-PEG4-Biotin is a Biotin-HaloTag ligand

CA-amide-PEG4-Biotin is a Biotin-HaloTag ligand that enables rapid labeling of Halo-tagged proteins and their efficient isolation via streptavidin pull-down

58 SMILES [2H]C([2H])([2H])OC1=CN=C(Cl)N=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

338 SMILES OCCOCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Molecular Weight Cannot read molecule file

2341796-77-6 (2HCl salt) Molecular Formula C29H45Cl2N5O4S Molecular Weight 630

Mal-Propionyl-PEG8-Val-Cit-PAB(m-PEG4)-Exatecan deuterium-labeled-ether CA-amide-PEG4-Biotin is a Biotin-HaloTag ligandSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG8 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I