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Simply put, p53 disturbs the equilibrium of pro-apoptotic and anti-apoptotic controllers, leading to the activation of the apoptotic executor Caspase-3, ultimately facilitating cell apoptosis

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3.7.2 MGBA disruption by RT Using RT in the abdomino-pelvic region can cause gut dysbiosis, due to the reduction of Firmicutes and Bacteroidetes species accompanied by the surge in Proteobacteria species