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8.9 Evidence strength summary of nutrients The Nutrient-Gut Microbiota Inhibition comprehensive evidence table systematically summarizes the evidence regarding the associations between five core nutrient categoriesprotein, Omega-3 polyunsaturated fatty acids, dietary fiber, vitamins, and mineralsand the Gut Microbiota Inhibition axis, as detailed in Sections 37 of the manuscript (Table 2)

A recent study showed that Trx1 attenuates cigarette smoke extract-induced endoplasmic reticulum (ER) stress, ROS production, mitochondrial dysfunction, and mitophagy-mediated inflammasome activation while enhancing the activation of the Nrf2/HO-1 signaling pathway, contributing to the improved antioxidant and anti-inflammatory response in murine lungs [130]

TRAF6 binds to and ubiquitinates Krppel-like factor 4 (KLF4), a complex transcription factor that acts as a tumor-promoting gene in NPC

The liver holds the reservoir for glutathione and supports the liver's detoxification processes

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