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10.1038/jid.2014.175 22 CarthyJ

Bypassing first-pass metabolism utilizes lymphatic delivery for direct access to systemic circulation, targeted release for site-specific delivery, and sustained release to reduce metabolic clearance

modulates matrix metalloproteinase activity

Ran J, Li F, Zhan L, Jin Y, Dong Q, Li X et al (2025) Hypoxia regulates glycolysis through the HIF-1/BMAL1/ALDOC axis to reduce oxaliplatin sensitivity in colorectal cancer