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doi:10.1592/phco.27.9.1219

Mol Cytogenet 9:84, 2016

Kapturczak, M

Oxidative stress can cause DNA damage, lipid peroxidation, protein oxidation, and mitochondrial dysfunction (81), all of which are associated with apoptosis in retinal ganglion cells

Hence intracellular proteins usually do not contain disulfides, which are abundant in extracellular proteins (such as those found in blood) or in certain organelles such as the endoplasmic reticulum and mitochondrial intermembrane space where disulfidesc can be introduced