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In AP, damage-associated molecular patterns (DAMPs) released from necrotic acinar cells, such as mitochondrial DNA, extracellular ATP, and reactive oxygen species (ROS), which activated NLRP3 inflammasome and resulted in perpetuating a vicious cycle of inflammation, pancreatic necrosis, and systemic inflammatory response syndrome (Papantoniou et al., 2024)

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The Challenge The JE Dunn team attempted to organize information on Excel spreadsheets, but with most documents stored in individuals computers, the information would only be periodically updatedand sometimes even lost