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The specific upstream triggers of each disease (such as A, ischemia and hemorrhage) activate these common downstream pathological processes, which in turn are the direct upstream activators of the core ferroptosis machinery (iron overload, lipid peroxidation and antioxidant system depletion)

1980 Oct 1;204(1):8087

All these observations were confirmed and supported by in vitro experimental data, including evaluation of cytotoxic effects on healthy RBCs [269,270,271]

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Sorafenib attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis via HIF-1/SLC7A11 pathway