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We first measured metabolite abundance in cells that were depleted of KG by glutamine starvation or treatment with the IDH1 inhibitor (Fig

( a-b ) Plasmid DNA was replicated in Xenopus egg extracts /+ IDH1i

Because corticosteroids can block pain and potentially enhance oxygen consumption, and because overuse can suppress ones immune system, the medication required an official therapeutic use exemption in order to be used in competition