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Importantly, supplementation with melatonin not only alleviates clinical symptoms related to OP, but also inhibits GM dysbiosis, promotes the function of GM, increases SCFA levels, reduces trimethylamine N-oxide (TMAO), and preserves intestinal barrier integrity (85) ( Figure 1 )

When administrated with a high-iron diet, the transferrin-knockout mice were susceptible to develop ferroptosis-induced liver fibrosis, which was significantly ameliorated with Fer1 treatment ( via the induction of ferroptosis in HSCs, which was mainly attributed to the upregulation of HO1 (53)

The PSM count for each protein in a specific sample was first normalized using the sum of the PSM counts for all proteins in that sample

Zhang C, Zuo T, Wang X, Wang H et al (2019a) Integration of data-dependent acquisition (DDA) and data-independent high-definition MSE (HDMSE) for the comprehensive profiling and characterization of multicomponents from Panax japonicus by UHPLC/IM-QTOF-MS

This phenomenon seems to occur because the expression of AtNDPK2 antagonizes the elevation of cytosolic H2O2 induced by stresses

Ritelli, M