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However, we should realize that to identify a given agent as a thyroid disruptor (and also any EDC) meets numerous difficulties, for example, exposure to usually only one (or just a few chosen) potential EDC under experimental conditions, and even our still limited knowledge regarding physiological processes in the thyroid resulting in diagnostic doubts which thyroid hormone concentration is normal or abnormal, etc

See, www.fda.gov/ucm/groups/fdagov-public/@fdagov-foods- gen/documents/document ucm264131.pdf

Journal of Clinical Neuroscience, 19 , 343348

2023 Sep 1:382:110636

For example, prolonged ferroptosis inhibition may promote tumorigenesis (by suppressing cell death in pre-malignant cells) or exacerbate other pathological processes (e.g., fibrosis) in ADPKD kidneys, risks that require rigorous evaluation in long-term animal models