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77 , e14e21 (2018)

Furthermore, pharmacotherapeutic trials targeting monoaminergic systemssuch as SSRIs and bupropionhave shown modest efficacy in reducing depressive symptoms in alcoholics, though their benefits are often overshadowed by high placebo response rates and relapse risk (Agabio et al

Jakubek Y, Lang W, Vattathil S, Garcia M, Xu L, Huang L, Yoo SY, Shen L, Lu W, Chow CW, Weber Z, Davies G, Huang J, Behrens C, Kalhor N, Moran C, Fujimoto J, Mehran R, El-Zein R, Swisher SG , Wang J, Fowler J, Spira AE, Ehli EA, Wistuba II, Scheet P, Kadara H