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Given the role of NAD + in modulating the processes described above, NAD + -boosting interventions are being investigated for supporting mitochondrial homeostasis

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Methods: Male C57/BL6J mice aged 8-9 week (wk) aged with subcutaneous implanted osmotic pump delivering 2.5mmol/kg/d of ammonium acetate (AmAc) or vehicle (PBS) for 6 wk were randomized to either voluntary wheel running (VWR) or usual activity (UA) for 4wk

Key inclusion criteria were as follows: previous participation in the IronAge Study (T0 and T1), which focused on assessing brain iron content and accumulation in a large participant pool [35] (but also sleep and metabolomics [36]) and consent to be contacted for follow-up studies

Palomar-Cros et al., 2023) and adjustment or control for diabetes (Bosetti et al., 2009

Usually, amphophilic foci are less frequently observed in rats and mice compared to other foci