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They just looked at Its a systematic review, so they just pulled all the papers that they could find up until 2024, and they specifically said that this is very scoping

[DOI] [PubMed] [Google Scholar] Janssen I, Heymsfield SB, Wang ZM, Ross R

In a clinical study, bortezomib was found to minimize proteinuria and improve renal symptoms in patients treated with lupus nephritis over an extended period

Water retention is significant enough to be visible or uncomfortable

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