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By blocking NNMT, 5-Amino-1MQ restores NAD+ availability, reactivates SIRT1-mediated mitochondrial biogenesis, and shifts substrate preference from glucose storage to lipid catabolism

This is important for their treatment

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Testing may include SAM, SAH, methionine, homocysteine, whole-blood histamine, copper, zinc, ceruloplasmin, urinary pyrroles, organic acids, lactate, pyruvate, glutathione-related markers, 8-OHdG and lipid peroxides when clinically appropriate

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