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In vitro studies demonstrated cytotoxic activity in HepG2 cells and human liver cells L-02, leading to cell death, and demonstrated in in vivo studies that flavokavain B is responsible for the potentiation of kava hepatotoxicity upon herbdrug interaction in C57BL/6 mice

This localized reaction typically resolves within hours to a few days, but understanding what's normal versus what warrants provider contact is critical

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In weight loss, HCG is sometimes used alongside a low-calorie diet to mobilize stored fat (though this remains controversial)

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In the phase 3 human trials of the r Sh 28GST vaccine candidate, PZQ was administered before and after the initial vaccination as well as just before and after the booster vaccination