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Another parallel-group comparative clinical study was designed to estimate the efficacy and safety of curcumin (CUC-01, 300 mg) combined with paclitaxel as compared to paclitaxel plus placebo in patients with metastatic and advanced breast cancer

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The atrophy of immune organs and diminished lymphocyte proliferation underscore a compromised immune competence directly linked to the malfunction of zinc finger proteins in cytokine gene regulation [11]

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The relatively low AUC of 0.64 for patient/carrier comparisons likely reflects overlap in age distribution, with many carriers already within the disease onset window, Supplemental Information Fig