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Unlike classical AKI models showing ROS-mediated pyruvate depletion (Legouis et al., 2022), our folate-injury model revealed elevated pyruvate, likely due to glycolytic surge overwhelming catabolism and MG-induced PDH/LDH inhibition

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In aggregate, these sequelae precipitate neuronal cell demise and concomitant neurological dysfunction, collectively encapsulated within the paradigm of EBI (11)

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