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High levels of choline, the source of TMAO, were associated with a 2.4-times greater incidence of the disease [29]

-Butyrobetaine Hydroxylase (BBOX) The final step in carnitine biosynthesis is the hydroxylation of -BB by BBOX, an enzyme localized in the mitochondria

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44 Other CPTI inhibitory drugs, such as perhexiline, is also proved to be toxic (such as neurotoxicity and hepatotoxicity) especially after long-term therapy