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In step 3 of the mechanistic process of lipid peroxidation, the lipid peroxyl free radical abstracts another labile allylic H-atom from the acyl chain resident on carbon-2 of glycerol backbone of a phospholipid to form a lipid hydroperoxide, LOOH, and produces another carbon-centered free radical on this acyl chain, which immediately will be attacked by another molecule of oxygen, again producing a lipid peroxyl free radical, LOO

Another study reported that the depletion of VHL, a major tumor suppressor of clear cell renal cell carcinoma (ccRCC), leads to the stabilization of the hypoxia inducible factors HIF-1 and HIF-2

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Nat Rev Mol Cell Biol 16:727741 Borgio JF (2010) RNAi mediated gene knockdown in sucking and chewing insect pests