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Role of inflammasome in severe, steroid-resistant asthma

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Svegliati-Baroni G, Pierantonelli I, Torquato P et al (2019) Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease

Atf3 is a stress-responsive transcription factor and Ddit3 is a known apoptosis-promoting transcription factor 40,41

Response monitoring should include subjective symptom tracking, functional assessments, and appropriate objective measures

Mendelian randomization has confirmed a significant association between PM2.5 exposure and increased genetic susceptibility to UC [240], Immigrant studies also indicate that individuals migrating from low-incidence to high-incidence areas have an elevated risk of IBD [241, 242], while high birth order ( 3), due to early exposure to infections, is associated with a reduced risk of IBD [243], These macro-epidemiological findings underscore the importance of the synergistic role of environmental changes and genetic background