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Available via Accessed 15 Jan 2020 Mayne ST (2013) Oxidative stress, dietary antioxidant supplements, and health:is the glass half full or half empty

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As a result of rapid hydrolysis, plasma concentrations of aspirin are always low and rarely exceed 20 ug/ml (111 uM) at ordinary therapeutic doses of 325 to 650 mg (Dovizio et al, 2013) Salicylate can also inhibit COX-1 and COX-2 with little selectivity if high enough plasma concentrations are achieved (Table 1)(Dovivzio et al, 2013): Salicylate IC50 for COX-1 = 1100 uM Salicylate IC50 for COX-2 = 1400 uM Salicylates are excreted mainly by the kidney

Biochem Soc T

Med Sci Monit 12(1):3645 Braverman AS, Vegesna AK, Miller LS et al (2011) Pharmacologic specificity of nicotinic receptor-mediated relaxation of muscarinic receptor precontracted human gastric clasp and sling muscle fibers within the gastroesophageal junction

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