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These groups might not get enough B12 because of their diet, age, or health issues

doi:10.1152/japplphysiol.00945.2010 (3) Berger DR, Centeno CJ, Steinmetz NJ

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A consistent model goes with ligation leading to vessel injury, exposure of tissue factors, stasis, thrombosis, hemodynamic changes, arterial hypotension, and in particular, venous hypertension, which approximates values over 20 mm Hg in the inferior caval vein, 101 thereby being roughly four times higher than those in normal rats

Rather than taking a high dose of one single one on its own, it's better to take a good combination

Altogether, these findings suggest a potential beneficial effect of vitamin B12 in reducing neuroinflammation and promoting neuroprotection in patients with persistent VCD long after experiencing mild acute COVID-19