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305 At the therapeutic level, therapeutic vaccines targeting Arg 1 have been shown to activate antitumor immunity in a variety of syngeneic mouse tumor models such as lung cancer, melanoma, and colon cancer, and the combination of Arg 1 vaccine with anti-PD-1 antibody can increase T cell infiltration, inhibit myeloid cell function, and increase the ratio of tumor-infiltrating M1/M2 macrophages

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The treatments lasted 4 days, and measurements continued for 4 more days to capture the recovery period

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Its levels decline with age, and that decline has been linked in research to disrupted communication between the cell nucleus and its mitochondria