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(1016) Leclercq, S

Evidence (cabozantinib): A phase III, randomized, double blind, placebo-controlled study (COSMIC-311 [NCT03690388]) was conducted to evaluate the efficacy of cabozantinib in patients aged 16 years and older with RAI-refractory differentiated thyroid cancer

Deficiencies in DCX expression or function are associated with severe neurodevelopmental disorders, such as lissencephaly and subcortical band heterotopia

Additionally, synthetic SOD mimetics are under investigation to replicate or improve the enzymes antioxidant activity while minimizing toxicity and immune responses

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This results in immune cells congregating in the thyroid gland, and eventually losing their ability to differentiate the thyroid gland from a foreign invader (like a virus or bacteria)