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Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis

These processes play key roles to promote chemoresistance in tumors, where elevated GSH inactivates electrophilic chemotherapeutic agents (cisplatin, alkylators), GSTs enable drug conjugation, and MRP-catalyzed efflux reduces intracellular drug levels - while inhibiting therapy-induced oxidative stress at the same time

The preservation of the anaerobic bacterial population, the regulation and segregation of mucosal immunometabolic activities, and the energy metabolism are all contingent upon intestinal oxygen tension

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Ma S, Dubin AE, Zhang Y, Mousavi SAR, Wang Y, Coombs AM, et al

Hargreaves RJ, Foster JR, Pelling D, Moorhouse SR, Gangolli SD, Rowland IR (1985) Changes in the distribution of histochemically localized mercury in the cns and in tissue levels of organic and inorganic mercury during the development of intoxication in methylmercury treated rats