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Multiple studies have confirmed significant dysbiosis of the gut microbiota in IBD patients

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doi: 10.1074/jbc.M116.750299

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Besides the biochemical importance of ONOO in living systems, newly confirmed in plant cells, HNO react with thiol-containing proteins/peptides (Arasimowicz-Jelonek et al

While NAFL is typically accompanied by a lower risk of liver-related mortality, it can progress to non-alcoholic steatohepatitis (NASH) ( Although there has been a lot of effort in developing non-invasive tools for NAFLD diagnosis, the diagnosis of NAFLD is mainly based on liver biopsy ( Exosomes are nanosized extracellular vesicles that have significant roles in the pathogenesis of different diseases ( 2 Exosomes Exosomes are bi-lipid membrane extracellular vesicles sized from 50 to 140 nm ( Exosome biogenesis involves complex intracellular pathways with distinct mechanisms for different EV subtypes ( Recognition of Ubiquitinated Cargo is the first step in exosome biogenesis ( Recent findings suggest the existence of an alternative pathway for sorting exosomal cargo into MVBs in an ESCRT-independent manner ( in vivo