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200 Promoting ferroptosis using GPX4 inhibitors The essential antioxidant enzyme GPX4 is not only responsible for maintaining redox homeostasis, but is also recognized as the ferroptosis gatekeeper by transforming lipid ROS into lipid alcohols

This diversity renders drug resistance extremely complex, necessitating multi-dimensional analytical and strategic approaches in both research and clinical applications

2018 Jan 11;2018:bcr2017221405

While the factors underlying brain health and longevity discussed below are not exhaustive, they represent what appear to be the most quantifiable and targetable factors underlying neurodegenerative processes along the MCI-ADRD continuum