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Cyclin-dependent Kinase Inhibitor p27Kip1 Controls Growth and Cell Cycle Progression in Human Uterine Leiomyoma

Melatonin protects the electron transport chain (ETC) by binding to the Fe-S cluster of NADPH dehydrogenase, reducing the generation of superoxide anion radicals (O2) caused by electron leakage, blocking the opening of the mitochondrial permeability transition pore (mPTP), and preventing apoptosis caused by cytochrome C leakage (Hardeland, 2017

Ven R, Castellani P, Delfino L, Lucibello M, Ciriolo MR, Rubartelli A

J., Abdel-Rehim, M

After centrifugation at 12,000 rpm for 10 min at 4 C, the supernatants were incubated with Flag beads at 4C overnight