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Black cumin and TQ showed therapeutic promises against ischemic stroke and traumatic brain injury as presented in several reviews [47,87]

Remarkably, the deletion of TST did not affect the protein expression of CBS and CSE in murine liver, suggesting that elevated circulating sulfide and thiosulfate level are a result of impaired sulfide oxidation and reduced thiosulfate utilization [39]

In this context, PS externalization indicates activation of eryptosis in senescent erythrocytes, suggesting that senescent erythrocytes exposing PS should be considered as eryptotic cells

These differences may be attributed to difference in sample size in each study

Rather than replacing levodopa, natural compounds may best serve as complementary therapies, addressing aspects such as dopaminergic neuron preservation, oxidative stress reduction, and inflammation control

Also, while Bax was involved in release of cytochrome c and Smac, this was not the case for endonuclease G and AIF [106], suggesting that these two proteins may be released by slightly differing mechanisms in contrast to cytochrome c and Smac