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The PICOs elements were defined as follows: P (Participants): subjects of any age diagnosed with Vitamin B12 deficiency

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These changes are caused by genetic and epigenetic changes in the tumor, and increased GSH was associated with epithelial-mesenchymal transition, local invasion, metastasis, and tumor survival [61, 62]

Researchers also study GHK-Cu in models associated with collagen signaling, extracellular matrix modulation, redox signaling pathways, and peptide-mediated cellular regulation