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More chronic, placebo-controlled human studies are required to evaluate not only the bioavailability and efficacy of various polyphenol formulations and delivery systems but also to establish standardized dosages, monitor potential side effects, and assess inter-individual differences in responses due to genetics and gut microbiota composition (126, 127)

Continuous-flow microfluidic systems enable controlled nanoparticle assembly with improved batch uniformity and reduced solvent consumption, making them suitable for large-scale manufacturing compared to traditional batch methods [115]

Resveratrol confers endothelial protection via activation of the antioxidant transcription factor Nrf2

Before birth, the OPCs proliferate and migrate throughout the CNS parenchyma, but myelination occurs principally during the postnatal period, when OPCs differentiate and become myelinating OLGs

A ROS responsive nanomedicine with enhanced photodynamic therapy via dual mechanisms: GSH depletion and biosynthesis inhibition

These effects translate to improved cardiac function and reduced structural damage, suggesting that viniferin may serve as a protective agent during ischemic events and cardiac surgeries (Peng et al