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This approach not only potentiated apoptosis but also blocked compensatory survival pathways, supporting its potential to overcome resistance in MSS CRC [160]

Production of these reactive oxygen species is known to occur as a result of a few different mechanisms: 1) mitochondrial origin in which free radicals either escape scavenging enzymes or develop due to an error in oxidative processes, 2) inside the capillary endothelium where a hypoxic and reoxygenation process is created during intense exercise as well as during various types of cardiovascular disease, and 3) an oxidative burst from inflammatory cells which are commonly mobilized as a result of the muscle or tissue damage which is well-documented with extended or eccentric-based exercise[1]

that might affect the metal levels in blood

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Vitamin C supports immune function and enhances antioxidant activity