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Angiogenesis, collagen synthesis, neuroprotection and inflammatory modulation compounds verified for preclinical research Tissue repair is a coordinated biological process involving angiogenesis (the formation of new blood vessels), fibroblast migration, collagen synthesis, and the modulation of the inflammatory response

(Liu et al., 2015) extended these findings, revealing a positive association between serum MNAM levels and obesity

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The first cardiovascular study of NNMT enzyme inhibition in a heart failure with preserved ejection fraction (HFpEF) mouse model demonstrated that treatment markedly reduced 1-MNA (by 77.1%), 2PY (by 66.2%), and 4PY (by 71.1%) in cardiac tissue, while improving cardiac function, enhancing global longitudinal strain, reversing peak longitudinal strain rate, and significantly reducing left ventricular hypertrophy and fibrosis

Khouri JF1

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