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Discussion GSSD is caused by genetic variations in GSS , which is located on chromosome 20q11.2, contains 13 exons, and is approximately 32 kb in length

Under conditions of oxidative stress, elevated levels of reactive oxygen species (ROS) oxidise key cysteine residues in KEAP1 (C226, C273 and C288), altering its conformation, thereby impairing the degradation of NRF2

IVDs Class 1 IVD and Class 1 IVD Export only (Regulation 3.9A) Class 2 IVD (Regulation 3.8A) Class 3 IVD (Regulation 3.7A) Class 4 IVD (Regulation 3.6A) Application audits Application audits are conducted to verify that devices submitted for inclusion in the ARTG meet the relevant legislative requirements

The washing buffer may contain low concentrations of non-ionic detergents or mild salts to enhance the removal of loosely bound contaminants without disrupting the GST-glutathione interaction