glutathione persister cells cancer

glutathione persister cells cancer Drug-tolerant are vulnerable to GPX4 inhibition Oncology Reports

Name: glutathione persister cells cancer Drug-tolerant are vulnerable to GPX4 inhibition Oncology Reports
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Oncology Reports Fighting Drug Resistance through the Targeting of Drug Tolerant Persister Cells Targeting drugtolerant cells: A promising strategy for overcoming acquired drug resistance in cancer cells Song 2023 MedComm Wiley Online Library Frontiers Drug tolerant persister cells in acute myeloid leukemia: pressing challenge and promising new strategies for treatment Glutathione peroxidase 4dependent glutathione highconsumption drives acquired platinum chemoresistance in lung cancerderived brain metastasis Liu 2021 Clinical and Translational Medicine Wiley Online Library Targeting of vulnerabilities of drug tolerant persisters identified through functional genetics delays tumor relapse ScienceDirect

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Inadequacies in antioxidant enzymes or their compromised metabolism will increase the concentration of reactive oxygen species (ROS) and, in essence, cause oxidative stress