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Suppression of NOD-like receptor protein 3 inflammasome activation and macrophage M1 polarization by hederagenin contributes to attenuation of sepsis-induced acute lung injury in rats

The cells were fixed, permeabilized, blocked with goat serum, and incubated with an antibody specific for cleaved SIRT1 and BDNF (1:200 dilution, Proteintech) at 4

This distinct microbial feature was intimately linked to the observed disturbances in epithelium barrier integrity and pro-inflammatory signaling in the intestine