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SIM-induced G1 cell cycle stopping in NCI-H460 cells is mediated by the upregulation of p16 and p27 proteins, and induces blockade of cyclin D-Cdk4 expression

Genetic Predisposition for Cytokine Storm Cytokine storm - also known as cytokine release syndrome or hypercytokinemia - represents a life-threatening over activation of the immune system where pro-inflammatory cytokines flood the body, leading to widespread inflammation, tissue damage, organ failure, and potentially death