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This formulation resulted in zero drug release over a 24-hour period though the reasons for this were unclear

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The build-up of such firing patterns occurs at the population level when sustained SST stimulation activates a hypothalamic circuit comprised of GHRH neurons, together with their GABAergic and glutamatergic inputs

Current Addiction Reports 2019, 6: 374-382

Cunnane SC, Trushina E, Morland C et al (2020) Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

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